Recent Advances on the Production of Itaconic Acid via the Fermentation and Metabolic Engineering

Itaconic acid (ITA) is one of the top 12 platform chemicals. The global ITA market expanding due to rising demand for bio-based unsaturated polyester resin and its non-toxic qualities. Although bioconversion using microbes main approach in current industrial production ITA, ecological faces several issues to: low efficiency, difficulty employ inexpensive raw materials, high manufacturing costs. As metabolic engineering advances, microorganisms offers a novel strategy promotion bio-production. In this review, most recent developments through fermentation are compiled from variety perspectives, including identification synthesis pathway, natural producers, design construction pathway model chassis, creation, as well application, new strategies production. challenges encountered bio-production microbial cell factories discussed, some suggestions future study also proposed, which it hoped insightful views promote cost-efficient sustainable ITA.